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Haplotype
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A set of closely linked genetic markers present on one chromosome which
tend to be inherited together (not easily separable by recombination).
Some haplotypes may be in linkage disequilibrium.
Definition
from:
Hypermedia Glossary Of Genetic Terms
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A set of closely linked alleles (genes or DNA polymorphisms) inherited as
a unit. A contraction of the phrase "haploid genotype". Different
combinations of polymorphisms are known as haplotypes. Collectively the
results from several loci could be referred to as a haplotype. "Haplo"
comes from the Greek word for "single
Definition
from:
Genetics/DNA Glossary
Heteroduplex
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DNA A double-stranded DNA molecule or a DNA/RNA hybrid where each strand
is from a different source
Definition
from:
Hypermedia Glossary Of Genetic Terms
-
A DNA double helix formed by annealing single strands from different
sources; if there is a sequence difference between the strands, the
heteroduplex may show single strand loops or bubbles (unpaired regions).
Definition
from:
http://www.biochem.northwestern.edu/holmgren/Glossary/Definitions/Def-H/heteroduplex.html
Heteroduplex analysis
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The study of the mobility of heteroduplex DNA under polyacrylamide gel
electrophoresis. The reduced mobility of heteroduplex DNA compared with
homoduplex DNA is proportional to the degree of divergence of the
sequences.
Definition
from:
http://www.igd.cornell.edu/MolecularMarkers/Glossary.pdf
Homoduplex
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DNA A double-stranded DNA molecule where both strands are from the same
source.
Definition
from:
Hypermedia Glossary Of Genetic Terms
Hot-start PCR
Is a modification of conventional PCR that reduces
non-specific product amplification. In this procedure amplification cannot occur
until the reaction temperature is above that where non-specific annealing of
primers to targets occurs. This block in amplification is usually accomplished
by using a DNA polymerase that is inactive until higher temperatures are
reached.
Quality
Assurance/Quality Control Guidance for Laboratories Performing PCR Analyses on
Environmental Samples
Hybridization
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The process of joining two complementary strands of DNA or one each of DNA
and RNA to form a double-stranded molecule. One strand is often labeled
and used as a probe to detect the presence of the second strand.
Definition
from:
Hypermedia Glossary Of Genetic Terms
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The joining together of complementary strands of DNA by the process of
base pairing when the two strands are from different sources. For example,
a DNA strand immobilized on a blot and its complementary radioactively
labeled DNA probe.
Definition
from:
genelex.com
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In molecular biology: the binding of
sequences to form a double-stranded structure.
Definition
from:
http://www.igd.cornell.edu/MolecularMarkers/Glossary.pdf
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